Galantamine hydrobromide is formulated in tablets and capsules prescribed through oral delivery for the treatment of\nAlzheimer�s disease. However, oral delivery of drugs can cause severe side effects such as nausea, vomiting, and gastrointestinal\ndisturbance. Transdermal delivery of galantamine hydrobromide could avoid these unwanted side effects. In this work, galantamine\nhydrobromide was formulated in gel drug reservoir which was then fabricated in the transdermal patch. The in vitro drug release\nstudies revealed that the drug release from the donor chamber to receptor chamber of Franz diffusion cell was affected by the\namount of polymer, amount of neutralizer, amount of drug, types of permeation enhancer, and amount of permeation enhancer.\nVisual observations of the gels showed that all formulated gels are translucent, homogeneous, smooth, and stable. These gels have\npH in the suitable range for skin. The gel also showed high drug content uniformity. Hence, this formulation can be further used\nin the preparation of transdermal patch drug delivery system.
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